Frank Avignone is the Carolina Endowed Professor of Physics and Astronomy at the University of South Carolina in Columbia, where he leads the Particle Astrophysics Group. He received a Ph.D. from the Georgia Institute of Technology as well as Doctor-Honoris-Causa degrees from the University of Buenos Aires, Argentina, and the University of Zaragoza, Spain. His main research activities are in neutrino physics. He is involved, in particular, in the neutrinoless double-beta decay experiments MAJORANA and CUORE. Frank Avignone was involved in the very early dark matter and solar-axion searches.