Synopsis: Like Prefers Like, Except in a Virus

A statistical model favors an unexpected mechanism for avoiding duplicated genetic material in certain viruses.
Synopsis figure
S. V. Venev and K. B. Zeldovich, Phys. Rev. Lett. (2012)

Influenza and certain other viruses have a segmented genome, in which each segment is a strand of RNA that codes for a particular protein. New viruses forming from the many genome copies in an infected cell must amass one of each type of segment—and no duplicates—in order to go on to infect other cells and replicate. A better understanding of how segments recognize each other to form a complete genome could therefore lead to new antiviral drugs. In Physical Review Letters, Sergey Venev and Konstantin Zeldovich at the University of Massachusetts Medical School, Worcester, use a simple statistical model to predict the most efficient segment-signaling mechanism for avoiding duplicated genetic material.

Venev and Zeldovich used a Monte Carlo algorithm to simulate the evolution of influenza A—a virus with eight segments in its genome—over 5000 generations. Their starting assumption was that each of the eight RNA segments had a random affinity for the other seven and itself. In each new generation of viruses, the segments were allowed to mutate, but only if these mutations increased the probability that a daughter virus had exactly eight unique segments.

The researchers found that identical segments evolved to repel each other—a surprise since it is generally believed that it is attractions between dissimilar segments that ensure a complete genome. Only high-resolution structural studies of viral genomes can reveal the true segment signaling mechanism, but Venev and Zeldovich’s work shows an interesting application of statistical physics to evolutionary biology. – Jessica Thomas


More Announcements »

Subject Areas

Biological PhysicsStatistical Physics

Previous Synopsis

Next Synopsis

Nonlinear Dynamics

Star-Shaped Waves

Read More »

Related Articles

Synopsis: Predicting the Thickness of Sea Ice

Synopsis: Predicting the Thickness of Sea Ice

A new solution to an old equation will make it easier to model the evolution of sea-ice thickness. Read More »

Focus: How Anesthesia Switches Off Consciousness
Biological Physics

Focus: How Anesthesia Switches Off Consciousness

A computer model of a network of neurons shows that a sudden breakdown in the net's ability to transmit information mimics the brain wave changes that accompany anesthesia. Read More »

Synopsis: Blink and You Won’t Miss It
Statistical Physics

Synopsis: Blink and You Won’t Miss It

Regular disruptions to an experiment can increase the uncertainty of a measured quantity, but don’t necessarily change its value. Read More »

More Articles