Synopsis: A floating apothecary

Levitation technique provides a way to solidify pharmaceutical drugs in a highly soluble form.
Synopsis figure
C. J. Benmore and J. K. R. Weber, Phys. Rev. X (2011)

In an effort to make medicinal drugs that dissolve more quickly on delivery, scientists at Argonne National Laboratory in Illinois are using the technique of acoustic levitation to prepare molecular gels and amorphous solids. The technique could prove important for preparing several drugs that are known to be insoluble in crystalline form.

Acoustic levitation uses the pressure from intense sound waves to suspend an object. The technique is widely used in microgravity experiments, but also provides a way to solidify the atoms or molecules in a liquid without the potentially contaminating effects of a container. In a paper published in the inaugural issue of the open-access journal Physical Review X, Chris Benmore and Richard Weber show this containerless method allows them to supercool liquid forms of several over-the-counter and prescription drugs into amorphous forms.

Benmore and Weber are able to form the amorphous solids in two different ways. Drugs such as ibuprofen (an anti-inflammatory) and clofoctol (an antibiotic) were first dissolved in ethanol and then droplets of the solution were allowed to evaporate while suspended in the levitator. In an alternative method, which works for the antihistamine cinnarizine, the team starts with a solid form of the drug, melts it into droplets with a laser and then suspends these droplets as they cool.

For now, these experiments are “proof of principle,” as the effectiveness and shelf life of the drugs in their new structural forms remain to be explored. – Jessica Thomas


Features

More Features »

Announcements

More Announcements »

Subject Areas

Materials Science

Next Synopsis

Astrophysics

Collisions on the sky

Read More »

Related Articles

Synopsis: Tackling Electronic Correlations
Condensed Matter Physics

Synopsis: Tackling Electronic Correlations

A new “first principles” simulation method could broaden the range of strongly correlated materials whose properties can be theoretically predicted. Read More »

Viewpoint: Hydrogen Hides Surprises at High Pressure
Condensed Matter Physics

Viewpoint: Hydrogen Hides Surprises at High Pressure

Measurements of the melting curve of hydrogen at unprecedentedly high pressures call for a refinement of the theories describing the material. Read More »

Viewpoint: Porous Materials Exhibit Granular-Like Stress Chains
Materials Science

Viewpoint: Porous Materials Exhibit Granular-Like Stress Chains

Simulations of porous materials exhibit internal stress patterns like those in granular materials, despite the fact that these two systems are practically “negative images” of each other. Read More »

More Articles